Soma Purana

Apolipoprotein E (ApoE) is a major cholesterol carrier that supports lipid transport and injury repair in the brain.  APOE  polymorphic alleles are the main genetic determinants of Alzheimer disease (AD) risk: individuals carrying the ε4 allele are at increased risk of AD compared with those carrying the more common ε3 allele, whereas the ε2 allele decreases risk. Presence of the  APOE  ε4 allele is also associated with increased risk for cerebral amyloid angiopathy and age-related cognitive decline during normal ageing.  APOE gene is on chromosome 19.  The APOE gene consists of four  exons  and three  introns , totaling 3597  base pairs .  Three alleles - E2, E3, and E4. E4 is an ancient allele. E3 increased in frequency in the last 200,000 years. Estimated Percentages of the U.S. Population with the Six Possible e2, e3 and e4 Pairs of the Apolipoprotein E (APOE) Gene The human  APOE  gene exists as three polymorphic alleles—ε2, ε3 and ε4—which have a worldwide freq

Ref. https://www.health.harvard.edu/mind-and-mood/alzheimers-in-the-family?utm_source=delivra&utm_medium=email&utm_campaign=GB20180228-Alzheimers&utm_id=830338&dlv-ga-memberid=11071083&mid=11071083&ml=830338 "Studies of family history say that if you have a close relative who has been diagnosed with Alzheimer's disease—the most common form of dementia in older adults—your risk increases by about 30%. This is a relative risk increase, meaning a 30% hike in your existing risk." What does this mean? "If you are age 65, the risk of being diagnosed with Alzheimer's is 2% per year, although this also means a 98% chance per year of not developing Alzheimer's. In absolute numbers, a 2% annual risk means that two out of 100 65-year-olds will develop dementia every year. Family history raises the 2% annual risk by about 30%, to 2.6% per year. That means going from 20 cases in a group of 1,000 to 26 in 1,000, or six additional cases i